C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/40 (2006.01) A61K 31/426 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2464068
To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with a-form crystal and .beta.-form crystal of (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenyleth- yl)amino]ethyl]acetanilide. The .alpha.-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The .beta.-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the .alpha.-form crystal.
L'invention porte sur de nouveaux cristaux utiles comme matériau de départ dans les remèdes contre le diabète. Ces cristaux sont des cristaux à forme alpha ou beta de (R)-2-(2-aminothiazol-4-yl)-4'-[2-(2-hydroxy-2-phényléthyl)amino]éthyl]acétanilide. Le cristal à forme alpha ne présente pas d'hygroscopicité, mais a une stabilité qui permet de l'utiliser en médecine et est utile pour la synthèse de masse dans la production industrielle. Le cristal à forme beta présente une hygroscopicité relativement faible et est également utile comme intermédiaire au cristal à forme alpha .
Awamura Yuji
Kawazoe Souichirou
Maruyama Tatsuya
Onda Kenichi
Sakamoto Kenichirou
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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