C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/06 (2006.01) A61K 31/7032 (2006.01) C07H 15/14 (2006.01)
Patent
CA 2666781
The invention relates to .alpha. -galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the .alpha.-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize .alpha.-galactoceramide analogs by a mere metathesis reaction. The .alpha. -galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
.L'invention concerne des analogues .alpha.-glactocéramides, leurs procédés de fabrication, et les composés intermédiaires utilisés dans ces procédés. Elle concerne également des compositions pharmaceutiques renfermant ces analogues .alpha.-glactocéramides. Les procédés de fabrication selon l'invention impliquent l'utilisation de composés intermédiaire insaturés qui permettent de synthétiser des analogues .alpha.-glactocéramides par une simple réaction de métathèse. Les analogues .alpha.-glactocéramides selon l'invention sont utilisés comme ingrédients actifs de compositions pharmaceutiques, notamment des compositions pharmaceutiques possédant des propriétés anti-cancéreuses.
Bonneville Marc
Dubreuil Didier
Lacone Vivien
Lecourt Thomas
Lependu Jacques
Centre National de La Recherche Scientifique
Goudreau Gage Dubuc
Institut National de La Sante Et de La Recherche Medicale (inser
Universite Paris Descartes
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