.alpha.-halomethyl derivatives of histamine and related...

Details .alpha.-halomethyl derivatives of histamine and related... .alpha.-halomethyl derivatives of histamine and related...

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/54 (2006.01)

Patent

CA 1111432

a-HALOMETHYL DERIVATIVES OF HISTAMINE AND RELATED COMPOUNDS ABSTRACT OF THE DISCLOSURE Novel halomethy1 derivatives of amines of the follow- ing general structure Image wherein Y is FCH2-, F2CH- or F3C-; R is hydrogen, alkyl- carbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or Image wherein R3 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each of R1 and R2 is hydrogen, or a straight or branched lower alkyl group of from 1 to 4 carbon atoms and may be the same or differ- ent or R1 is hydrogen and Rz is fluorine; and pharmaceu- tically acceptable salts and individual optical isomers thereof.

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