Alpha-helical mimetics

Details Alpha-helical mimetics Alpha-helical mimetics

C - Chemistry, Metallurgy

07

C

C07C 275/50 (2006.01) A61K 31/17 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07C 275/54 (2006.01)

Patent

CA 2570213

Benzoyl urea derivatives that are alpha helical peptide mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell- targeting moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralising pro-survival Bcl-2 proteins. Use of the benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.

Des dérivés d'urée de benzoyle qui sont des mimétismes de peptide à hélice alpha qui miment seulement des protéines BH3, des compositions les contenant, leur association à des groupes caractéristiques à cibles cellulaires, et leur utilisation dans la régulation de la mort des cellules sont divulgués Les dérivés d'urée de benzoyle sont capables de se lier et de neutraliser des protéines pro-survivantes Bcl-2. L'usage des dérivés d'urée de benzoyle dans le traitement et/ou la prophylaxie de maladies ou de conditions associées à un dérèglement de la mort des cellules sont également divulgués.

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