.alpha.-helical protein based materials and methods for...

D - Textiles – Paper – 01 – F

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D01F 4/00 (2006.01)

Patent

CA 2473772

The invention relates to a method of producing useful materials from filament- forming .alpha.-helical proteins or filaments made of such proteins. The method comprises allowing filament-forming .alpha.-helical proteins to self- assemble into .alpha.-helix containing filaments and forming fibres, films or bulk materials from the filaments. The materials are stretched to strain the filaments so that the .alpha.-helices substantially irreversibly change to .beta.-sheet forms. The filament-forming .alpha.-helical proteins can comprise intermediate filament proteins. In a specific embodiment, the filament-forming proteins comprise hagfish slime thread IF proteins.

L'invention concerne un procédé de production de matériaux utiles à partir de protéines hélicoïdales alpha formant des filaments, ou de filaments fabriqués à partir de ces protéines. Ce procédé consiste à permettre à des protéines hélicoïdales alpha formant des filaments de s'auto-assembler en filaments contenant des protéines hélicoïdales alpha et de former des fibres, des films ou des matériaux en vrac à partir des filaments. Les matériaux sont étirés pour contraindre les filaments de telle sorte que les protéines hélicoïdales alpha modifient de manière sensiblement irréversible les formes de feuilles beta . Les protéines hélicoïdales alpha formant des filaments peuvent comprendre des protéines de filaments intermédiaires. Dans un mode de réalisation spécifique, les protéines formant des filaments comprennent des filaments intermédiaires de protéines de dépôts de myxines.

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