C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/44 (2006.01) A61K 31/19 (2006.01) C07C 317/46 (2006.01) C07C 317/48 (2006.01) C07C 317/50 (2006.01)
Patent
CA 2310401
The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted-(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted - (CH2)h-heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4 (X is -O- , -S(=O)j-, -NR7-, -S(=O)2NR8-, or -C(=O)-), and -(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
La présente invention concerne un composé de formule (I), ou des sels pharmaceutiquement acceptables de ce composé, formule dans laquelle R¿1? représente C¿4-12? alkyle, C¿4-12? alkényle, C¿4-12? alkynyle, -(CH¿2?)¿h?-C¿3-8? cycloalkyle, (CH¿2?)¿h-? aryle substitué ou non substitué, -(CH¿2?)¿h?-het substitué ou non substitué, R¿2? représente C¿1-12? alkyle substitué ou non substitué, C¿2-12? alkényle substitué ou non substitué, C¿2-12? alkynyle substitué ou non substitué, -(CH¿2?)¿h?-C¿3-8? cycloalkyle substitué ou non substitué, -(CH¿2?)¿h?-C¿3-8? cycloalkyle substitué ou non substitué, -(CH¿2?)¿h? aryle substitué ou non substitué, -(CH¿2?)¿h?- noyau hétérocyclique substitué ou non substitué, -(CH¿2?)¿i?-X-R¿4? substitué ou non substitué (X représentant -O-, -S(=O)¿j?-, -NR¿7?-, -S(=O)¿2?NR¿8?-, ou -C(=O)-), et (CH¿2?)¿j?CHR¿5?R¿6?. Ces composés sont des inhibiteurs des métalloprotéinases matricielles impliquées dans la dégradation tissulaire.
Harper Donald E.
Maggiora Linda Louise
Mitchell Mark Allen
Warpehoski Martha A.
Pharmacia & Upjohn Company
Robic
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