Alpha-hydroxy sulfonate aldehydes, germicidal compositions...

A - Human Necessities – 01 – N

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A01N 41/04 (2006.01) A01N 25/02 (2006.01) A01N 31/08 (2006.01) A01N 35/02 (2006.01) A01N 41/08 (2006.01) A61K 31/10 (2006.01) A61K 31/11 (2006.01) A61K 31/255 (2006.01) A61L 2/18 (2006.01) C11D 1/12 (2006.01) C11D 3/20 (2006.01)

Patent

CA 2494419

Disclosed herein are .alpha.-Hydroxy sulfonate aldehydes and synthesis methods therefor. Germicidal compositions including the .alpha.-hydroxy sulfonate aldehydes, are also disclosed. In one aspect, a germicidal composition may include a diluent, and a germicidally effective amount of a water-soluble germicidal compound including an aldehyde group and an .alpha.-hydroxy sulfonate group. The water-soluble compound may have a solubility of at least 5 (w/v)% in water. In a further aspect, the compound may include 1-hydroxy-3-oxo-2-phenyl-propane-1-sulfonic acid salt, (2-formyl- phenyl)- hydroxy-methane sulfonic acid salt, 1-hydroxy-2-(4-methanesulfonyl-2-nitro- phenyl)-3- oxo-propane-1-sulfonic acid salt, 2-bromo-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, 2-chloro-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, 2-(1-formyl-2-hydroxy-2- sulfo- ethyl)-isonicotinic acid salt, 2-benzooxazol-2-yl-1-hydroxy-3-oxo-propane-1- sulfonic acid salt, or 1-hydroxy-2-(4-methoxy-phenyl)-3-oxo-propane-1-sulfonic acid salt. Germicidal compositions including a mixture of an a-hydroxy sulfonate aldehyde and one or more phthalaldehydes, such as phthalaldehyde, isophthalaldehyde, terephthalaldehyde, or a combination thereof, are also disclosed. Methods of using the compounds or compositions for killing bacteria, disinfection, or sterilization, are also disclosed.

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