C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/56 (2006.01) A61K 31/166 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/455 (2006.01) A61P 25/28 (2006.01) C07C 233/76 (2006.01) C07C 237/22 (2006.01) C07C 237/42 (2006.01) C07C 255/13 (2006.01) C07C 271/22 (2006.01) C07C 317/50 (2006.01) C07C 323/42 (2006.01) C07C 323/59 (2006.01) C07D 213/56 (2006.01) C07D 213/82 (2006.01) C07D 263/48 (2006.01) C07D 303/48 (2006.01)
Patent
CA 2453447
The present invention relates to compounds of formula (I): Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment of reduce A beta peptide formation.
L'invention concerne des composés représentés par la formule (I) : (I), qui sont utiles pour le traitement de la maladie d'Alzheimer et d'autres maladies similaires. Ces composés comprennent des inhibiteurs de bêta secrétase utiles pour le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt du peptide A bêta chez un mammifère. Ces composés conviennent pour des compositions pharmaceutiques et des traitements permettant de réduire la formation de peptides A bêta.
Chrusciel Robert Alan
Schostarez Heinrich Josef
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company Llc
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