.alpha.(isoxazole or isothiazole)-.alpha.-phenylmethane...

Details .alpha.(isoxazole or isothiazole)-.alpha.-phenylmethane... .alpha.(isoxazole or isothiazole)-.alpha.-phenylmethane...

C - Chemistry, Metallurgy

07

D

167/208, 167/231

C07D 261/08 (2006.01) C07D 275/02 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1266664

X-6639 ABSTRACT OF THE DISCLOSURE Isoxazole- and isothiazole-5-methanes having two phenyl rings, or a phenyl and a pyridine ring on the methane, which phenyls may have up to two substituents, are useful for the physiological inhibition of the enzyme aromatase in the body, and are accordingly usable pharmaceutically for the inhibition of endogenous estrogen production and the treatment of estrogen- dependent diseases.

483672

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