C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/716 (2006.01) A61K 31/225 (2006.01) A61P 35/00 (2006.01) C07D 311/72 (2006.01)
Patent
CA 2574597
The present invention relates generally to the field of pharmaceuticals and medicine. More particularly, the present invention relates to certain compounds (e.g., .alpha.-ketoglutarate compounds; compounds that activate HIF.alpha. hydroxylase; compounds that increases the level of .alpha. ketoglutarate, etc.) and their use in medicine, for example, in the treatment of cancer (e.g., cancer in which the activity of one of the enzymes in the tricarboxylic acid (TCA) cycle is down regulated), in the treatment of angiogenesis (e.g., hypoxia-induced angiogenesis). One preferred class of compounds are .alpha.-ketoglutarate compounds having a hydrophobic moiety that is, or is part of, an ester group formed from one of the acid groups of .alpha. ketogluartic acid; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, N oxides, chemically protected forms, and prodrugs thereof.
La présente invention concerne en général le domaine des produits pharmaceutiques et de la médecine. Plus particulièrement, la présente invention concerne certains composés (par exemple les composés d~.alpha.-kétoglutarate ; les composés activant l~HIF.alpha. hydroxylase ; les composés augmentant le niveau d~.alpha.-kétoglutarate, etc.) et leur utilisation en médecine, par exemple, dans le traitement du cancer (par exemple du cancer dans lequel l~activité de l~une des enzymes dans le cycle de l~acide tricarboxylique(TCA) est régulée négativement), dans le traitement de l~angiogénèse (par exemple de l~angiogénèse induite par l~hypoxie). Une classe préférée de composés est constituée par les composés d~.alpha.-kétoglutarate ayant un fragment hydrophobe qui est ou qui fait partie d~un groupe ester constitué à partir d~un des groupes acides de l~acide .alpha.-kétoglutarique ; et de ses sels pharmaceutiquement acceptables, ses solvates, ses amides, ses esters, ses éthers, ses N oxydes, ses formes chimiquement protégées et ses promédicaments.
Gottlieb Eyal
Mackenzie Elaine D.
Selak Mary A.
Watson David G.
Cancer Research Technology Limited
Kirby Eades Gale Baker
LandOfFree
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