Alpha-lactalbumin gene constructs

Details Alpha-lactalbumin gene constructs Alpha-lactalbumin gene constructs

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A23C 9/00 (2006.01) A23C 9/20 (2006.01) C07K 14/76 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2193513

The present invention provides recombinant gene constructs for expressing the protein .alpha.-lactalbumin, especially human .alpha.-lactalbumin, in bovine cells. Novel genetic constructs, vectors and transformed cells are provided as well as transgenic animals genetically engineered for enhanced expression of .alpha.-lactalbumin. Human .alpha.-lactalbumin has been shown to be superior for human infant nutrition and the present invention enables a cheap and effective form for production of the major whey protein in human milk.

Structures géniques recombinées destinées à exprimer dans des cellules bovines la protéine .alpha.-lactalbumine, notamment l'.alpha.-lactalbumine humaine. On décrit des nouvelles structures géniques, des vecteurs et des cellules modifiées, de même que des animaux transgéniques obtenus par génie génétique, aux fins d'une expression accrue de l'.alpha.-lactalbumine. L'.alpha.-lactalbumine humaine s'est révélée être supérieure pour la nutrition de l'enfant, et la présente invention permet d'obtenir une forme de production bon marché et efficace, dans le lait humain, de la protéine principale du petit lait.

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