.alpha.-lipoic acid nanoparticles and methods for preparing...

Details .alpha.-lipoic acid nanoparticles and methods for preparing... .alpha.-lipoic acid nanoparticles and methods for preparing...

A - Human Necessities

61

K

A61K 31/385 (2006.01) A61K 9/14 (2006.01) A61K 47/02 (2006.01) A61K 47/34 (2006.01) A61P 1/02 (2006.01) A61P 17/00 (2006.01) A61P 39/06 (2006.01) C07D 339/04 (2006.01)

Patent

CA 2707010

Provision of a stable .alpha.-lipoic acid. A method for producing .alpha.-lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing .alpha.-lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming .alpha.-lipoic acid nanoparticles.

L'invention a pour objet un acide a-lipoïque stable. L'invention a également pour objet un procédé de fabrication de nanoparticules d'acide a-lipoïque, qui comprend une étape consistant à préparer un liquide de dispersion aqueuse contenant de l'acide a-lipoïque et un agent tensioactif non ionique; une étape consistant à ajouter un sel métallique divalent dans le liquide de dispersion aqueuse, le sel métallique divalent étant un halogénure métallique divalent, un acétate métallique divalent ou un gluconate métallique divalent; et une étape consistant à ajouter un carbonate métallique alcalin ou un phosphate métallique alcalin dans le liquide de dispersion aqueuse, à laquelle le sel métallique divalent a été ajouté, d'où la formation de nanoparticules d'acide a-lipoïque.

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