C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 335/20 (2006.01) A61K 31/17 (2006.01) A61K 31/34 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61P 31/22 (2006.01) C07C 335/20 (2006.01) C07D 213/81 (2006.01) C07D 215/48 (2006.01) C07D 215/54 (2006.01) C07D 217/06 (2006.01) C07D 217/26 (2006.01) C07D 263/34 (2006.01) C07D 277/56 (2006.01) C07D 285/06 (2006.01) C07D 307/68 (2006.01) C07D 307/81 (2006.01) C07D 307/85 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2350833
Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen,-CN,-NO2,-CO2R6,-COR6,-OR6,-SR6,-SOR6,- SO2R6,-CONR7R8,-NR6N(R7R8),-N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3, or R3 and R4, taken together to form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is -(CO)- or-(CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms,-CN,-CO2R6, COR6,-CONR7R8,-OCOR6,-NR6COR7,-OCONR6,-OR6,-SR6,-SOR6,- SO2R6, SR6N(R7R8),-N(R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond,-NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella- zoster virus, human herpesviruses-6 and-7, and Kaposi herpesvirus.
La présente invention concerne des composés représentés par la formule générale (I). Dans cette formule, R¿1?-R¿5? sont indépendamment hydrogène, C¿1?-C¿6? alkyle, C¿2?-C¿6? alcényle, C¿2?-C¿6? alkynyle, C¿1?-C¿6? perhaloalkyle, C¿3?-C¿10? cycloalkyle, hétérocycloalkyle de 3 à 10 segments carbon, aryle, hétéroaryle, halogène,-CN,-NO¿2?,-CO¿2?R¿6?,-COR¿6?,-OR¿6?,-SR¿6?,-SOR¿6?,-SO¿2?R¿6?,-CONR¿7?R¿8?,-NR¿6?N(R¿7?R¿8?),-N(R¿7?R¿8?) ou W-Y-(CH¿2?)¿n?-Z, l'un au moins des R¿1?-R¿5? ne devant pas être hydrogène; ou R¿2? pris avec R¿3?, ou R¿3? pris avec R¿4?, forment un hétérocycloalkyle de 3 à 7 segments ou un hétéroaryle de 3 à 7 segments; R¿6? et R¿7? sont indépendamment hydrogène, C¿1?-C¿6? alkyle, C¿1?-C¿6? perhaloalkyle, ou aryle; R¿8? est hydrogène, C¿1?-C¿6? alkyle, C¿1?-C¿6? perhaloalkyle, C¿3?-C¿10? cycloalkyle, hétérocycloalkyle de 3 à 10 segments, aryle ou hétéroaryle, ou R¿7? pris avec R¿8?, peut former un hétérocycloalkyle de 3 à 7 segments; W est O, NR¿6?, ou est absent; Y est-(CO)- ou (CO¿2?)-, ou est absent; Z est C¿1?-C¿4? alkyle,-CN,-CO¿2?R¿6?, -COR¿6?,-CONR¿7?R¿8?,-OCOR¿6?,-NR¿6?COR¿7?,-OCONR¿6?,-OR¿6?,-SR¿6?,-SOR¿6?,-SO¿2?R¿6?, -SR¿6?N(R¿7?R¿8?),-N(R¿7?R¿8?) ou phényle; G est aryle ou hétéroaryle bicyclique fusionné; X est une liaison,NH, C¿1?-C¿6? alkyle, C¿1?-C¿6? alcényle, C¿1?-C¿6? alcoxy, C¿1?-C¿6? thioalkyle, C¿1?-C¿6? alkylamino, ou (CH)J; J est C¿1?-C¿6? alkyle, C¿3?-C¿7? cycloalkyle, phényle ou benzyle; et n est un entier valant de 1 à 6. Ces composés conviennent au traitement d'affections associées aux virus de l'herpès, y-compris le cytomégalovirus humain, les herpèsvirus simplex, le virus d'Epstein-Barr, le virus de la varicelle-zona, les herpèsvirus 6 et 7 humains, et l'herpèsvirus de Kaposi.
Bloom Jonathan David
Curran Kevin Joseph
Digrandi Martin Joseph
Dushin Russell George
Lang Stanley Albert
American Home Products Corporation
Smart & Biggar
Wyeth
LandOfFree
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