C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/19 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/21 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61P 25/28 (2006.01) C07D 211/28 (2006.01) C07D 213/74 (2006.01) C07D 271/06 (2006.01) C07D 271/10 (2006.01) C07D 285/01 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 295/192 (2006.01)
Patent
CA 2471099
There is provided a series of novel .alpha.-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of .beta.-amyloid peptide (.beta.-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti- amyloid activity.
L'invention a trait à une série de nouveaux composés de .alpha.-(N-sulfonamido)acétamide de formule (I), dans laquelle R, R?1¿, R?2¿ et R?3¿, définis dans la description, sont des inhibiteurs de la production du peptide .beta.-amyloïde (.beta.-AP) et sont utilisés dans le traitement de la maladie d'Alzheimer et d'autres états pathologiques atteints par l'activité anti-amyloïde.
Bergstrom Carl P.
Bronson Joanne J.
Gai Yonghua
Macor John E.
Marcin Lawrence R.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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