A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/10 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2374001
The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present invention comprise an alpha- or beta- emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. The methods of treating a patient can include administering one or more clearing agents to the patient in conjunction with the radioimmunoconjugate of the present invention, as well as subsequently grafting bone-marrow or autologous stem-cells to the patient.
L'invention concerne des radioimmunoconjugués utiles dans la radioimmunothérapie ciblée et des méthodes de traitement d'un patient au moyen desdits radioimmunoconjugués. Les radioimmunoconjugués de l'invention comprennent un radio-isotope émettant des particules alpha ou bêta, et un site de liaison lié à ou placé sur un fragment de combinaison avec l'antigène, d'un anticorps se liant spécifiquement à un antigène spécifique de tumeurs. Les méthodes de traitement d'un patient peuvent consister à administrer un ou plusieurs agents de nettoyage au patient, conjointement avec le radioimmunoconjugué de l'invention, et à greffer des cellules souches autologues ou de moelle osseuse au patient.
Behr Thomas M.
Goldenberg David M.
Center For Molecular Medicine And Immunology
Smart & Biggar
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