.alpha.-phenyl-2-(aza)benzothiazolythioglycolic acids and...

Details .alpha.-phenyl-2-(aza)benzothiazolythioglycolic acids and... .alpha.-phenyl-2-(aza)benzothiazolythioglycolic acids and...

C - Chemistry, Metallurgy

07

D

260/273, 260/309

C07D 277/74 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1169066

ABSTRACT OF THE DISCLOSURE The invention relates to .alpha.-phenyl-2-(aza)bensothiazolyl- thioglycolic acids, derivatives thereof and pharmacologically acceptable salts thereof. The compounds are useful as modulators of the immune response. The compounds have the formula I: Image wherein R1 is hydrogen, halo, nitro, amino, lower alkyl, lower alkoxy, trifluoromethyl or hydroxy; R2 is halo, lower alkyl, lower alkoxy, amino, nitro or trifluoromethyl; R3 is amino, N-(lower)alkanoylamino(lower)alkoxy or N-arylcarbamoyl(lower)- alkylthio; X is CH or N; where the dotted lines represent optional double bonds in the 5,6 and 7,8 positions.

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