C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/30 (2006.01) C07F 9/40 (2006.01) C07F 9/547 (2006.01) C07F 9/572 (2006.01) C07F 9/58 (2006.01) C07F 9/60 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01)
Patent
CA 2155986
.alpha.-Phosphonosulfinate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula Image wherein R2 is OR5 or R5a; R3 and R5 are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R5a is alkyl, arylalkyl or aryl; R4 is H or pharmaceutically acceptable cation;, Z is H, halogen, lower alkyl or lower alkenyl; and R1 is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; as further defined above; including pharmaceutically acceptable salts.
Biller Scott A.
Fryszman Olga M.
Lawrence R. Michael
Biller Scott A.
Fryszman Olga M.
Lawrence R. Michael
Osler Hoskin & Harcourt Llp
LandOfFree
.alpha.-phosphonosulfinate squalene synthetase inhibitors... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .alpha.-phosphonosulfinate squalene synthetase inhibitors..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.-phosphonosulfinate squalene synthetase inhibitors... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1899261