.alpha. substituted-1-benzyl-naphthyls

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 295/088 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/21 (2006.01) A61K 31/275 (2006.01) A61K 31/395 (2006.01) C07C 217/18 (2006.01) C07C 233/18 (2006.01) C07C 255/13 (2006.01) C07C 323/16 (2006.01) C07D 207/06 (2006.01) C07D 211/14 (2006.01) C07D 265/30 (2006.01) C07D 295/092 (2006.01) C07D 295/096 (2006.01) C07D 295/30 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2171403

This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1- benzyl-naphthyls which are .alpha.-substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.

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