Alpha-substituted arylalkyl phosphonate derivatives

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/662 (2006.01) A61K 31/42 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61K 31/4965 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) C07F 9/02 (2006.01) C07F 9/28 (2006.01) C07F 9/40 (2006.01) C07F 9/58 (2006.01) C07F 9/6509 (2006.01) C07F 9/653 (2006.01) C07F 9/6539 (2006.01)

Patent

CA 2476027

The present invention relates to novel .alpha.-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

La présente invention a trait à de nouveaux dérivés d'arylalkylphosphonate .alpha.-substitués et leurs utilisations pour la réduction de concentrations plasmiques de lipoprotéines associées à l'apo (a), Lp(a), apo B, apo B (lipoprotéines de basse densité et lipoprotéines de très basse densité) et pour la réduction de concentrations plasmiques de cholestérol total.

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