Alpha substituted carboxylic acid as ppar modulators

Details Alpha substituted carboxylic acid as ppar modulators Alpha substituted carboxylic acid as ppar modulators

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) C07C 59/125 (2006.01) C07C 61/04 (2006.01) C07D 213/66 (2006.01) C07D 249/06 (2006.01) C07D 307/79 (2006.01) C07D 401/04 (2006.01) C07D 405/06 (2006.01) C07D 411/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2521915

Alpha substituted carboxylic acids of formula (I): wherein R' and R2 are as defined in the specification and R3 is A) formula (II); B) formula (III); C) formula (IV); and D) formula (V); wherein Y, Art, Are, AP, R4, R5, R6, R7, R6, R9, R9a, R10, R", R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR .alpha./y related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.

L'invention concerne des acides carboxyliques alpha-substitués de formule (I), dans laquelle R?1¿ et R?2¿ ont la définition donnée dans la description et R?3¿ est représenté par les formules (A), (B), (C) et (D), dans lesquelles Y, Ar?1¿, Ar?2¿, Ar?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?9a¿, R?10¿, R?11¿, R?12¿, R?17¿, le cycle A, et p ont la définition donnée dans la description ; et des compositions pharmaceutiques qui contiennent des quantités efficaces de ces composés ou de leurs sels utiles pour traiter des troubles associés au PPAR, plus spécifiquement au PPAR .alpha./.gamma., tels que le diabète, la dyslipidémie, l'obésité et les maladies inflammatoires.

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