.alpha.-substituted carboxylic acid derivatives

Details .alpha.-substituted carboxylic acid derivatives .alpha.-substituted carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 235/16 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/7056 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 25/00 (2006.01) A61P 27/12 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 235/06 (2006.01) C07D 235/12 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07H 17/02 (2006.01)

Patent

CA 2369871

.alpha.-Substituted carboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts of the same, or pharmacologically acceptable esters or amides thereof, which are useful as therapeutic and/or preventive agents for diabetes, impaired glucose tolerance, diabetes in pregnancy, and so on; wherein R1 is alkyl or the like; R2 is hydrogen or the like; R3 is hydrogen or the like; A is =CH- or the like; B is oxygen or the like; W1 is C1-C8 alkylene; W2 is a single bond or C1-C8 alkylene; X is hydrogen or the like; Y is oxygen or the like; and Z1 is alkoxy or the like.

L'invention concerne des dérivés d'acide carboxylique .alpha.-substitués de formule générale (I), leurs sels pharmaceutiquement acceptables ou leurs esters ou amides pharmaceutiquement acceptables utiles comme agents thérapeutiques et/ou préventifs pour le diabète, l'intolérance au glucose, le diabète lors de la grossesse, etc. Dans la formule (I) R¿1? désigne un alkyle ou analogue ; R¿2? désigne un hydrogène ou analogue ; R¿3? désigne un hydrogène ou analogue ; A désigne =CH- ou analogue ; B désigne un oxygène ou analogue ; W¿1? désigne un alkylène C¿1?-C8 ; W¿2? désigne une liaison simple ou un alkylène C¿1?-C¿8? ; X désigne un hydrogène ou analogue ; Y désigne un oxygène ou analogue et Z¿1? désigne un alcoxy ou analogue.

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