.alpha.-substituted negamycin derivatives and syntheses

Details .alpha.-substituted negamycin derivatives and syntheses .alpha.-substituted negamycin derivatives and syntheses

C - Chemistry, Metallurgy

07

C

260/525.3

C07C 109/097 (1980.01)

Patent

CA 1083175

.delta.-SUBSTITUTED NEGAMYCIN DERIVATIVES AND SYNTHESES ABSTRACT Compounds having the structure Image were found to be antibacterial agents and were synthesized by a process which comprises a) reacting diazomethane in the presence of boran trifluoride etherate with a conventional, easily removable ester of amino-protected negamycin to form the intermediate having the formula Image wherein A is hydrogen and B is a monovalent amino- protective group or A together with B are a divalent amino-protective group and b) removing from said intermediate the amino- protective groups A and B and the methyl ester group to form O-methylnegamycin.

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