C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/587 (2006.01) A61K 31/202 (2006.01) A61K 31/232 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 29/00 (2006.01) C07C 57/13 (2006.01) C07C 69/602 (2006.01) C07C 69/732 (2006.01) C07C 69/734 (2006.01) C07C 229/30 (2006.01) C07C 323/54 (2006.01) C11C 3/00 (2006.01) A61K 49/00 (2006.01)
Patent
CA 2667211
Omega-3 lipid compounds of the general formula (I): wherein R1 and R2 are the same or different and may be selected from a group of substitu- ents consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an al- kynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a car- boxy group, an alkylsulfmyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; - X represents a carboxylic acid or a derivative thereof, a carboxylate, a carboxylic anhydride or a carboxamide; and - Y is a C16 to C22 alkene with two or more double bonds, having E and/or Z configuration, are disclosed. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments in particular for the treatment of cardiovascular and metabolic diseases.
Composés lipidiques oméga 3 de formule générale (I), R1 et R2 étant identiques ou différents et pouvant être sélectionnés dans un groupe de substituants qui comprend: atome d'hydrogène, groupe hydroxy, groupe alkyle, atome halogène, groupe alcoxy, groupe acyloxy, groupe acyle, groupe alcényle, groupe alkynyle, groupe aryle, groupe alklythio, groupe alkoxycarbonyle, groupe carboxy, groupe alkylsulfmyle, groupe alkylsulfonyle, groupe amino, et groupe alkylamino; -X est un acide carboxylique ou un dérivé correspondant, un carboxylate, un anhydride carboxylique ou un carboxymide; et -Y est un alkène C16 à C22 à deux ou plus de deux liaisons doubles, de configuration E et/ou Z. Egalement, compositions pharmaceutiques et compositions lipidiques renfermant ces composés, et composés en question destinés à être utilisés comme médicaments en particulier pour le traitement de maladies cardio-vasculaires et métaboliques.
Bryhn Morten
Holmeide Anne Kristin
Rosman Jenny
Blake Cassels & Graydon Llp
Pronova Biopharma Norge As
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