C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/32 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 207/38 (2006.01) C07D 217/24 (2006.01) C07D 239/88 (2006.01) C07D 239/96 (2006.01) C07D 243/08 (2006.01) C07D 253/08 (2006.01) C07D 265/22 (2006.01) C07D 279/08 (2006.01) C07D 401/04 (2006.01) C07D 473/04 (2006.01) C07D 473/10 (2006.01)
Patent
CA 2247772
Disclosed herein are an .alpha.-substituted phenylpropionic acid derivative represented by the following general formula (1): (see fig. I) wherein W is a (substituted) lactam ring, A is an alkylene or alkyleneoxy group or the like, X is O, S, NH or CH2, Y1 is an amino, hydroxy or lower alkoxy group, R1 is H, alkyl group or the like, R2 is an alkyl or phenyl group or the like, and R3 is H, alkyl or alkoxy group or the like, or a salt thereof, and a medicine comprising such a compound as an active ingredient. The compound is excellent in the effect of lowering blood glucose and lipid.
Divulgation d'un dérivé de l'acide phénylpropionique substitué en .alpha., représenté par la formule générale suivante (I) : (voir fig. I), dans laquelle W est un noyau de lactame (substitué), A est un alkylène ou un alkylèneoxy ou un groupement semblable; X est O, S, NH ou CH2; Y1 est un amino, un hydroxy ou un alcoxy léger; R1 est H, un alkyle ou un groupement semblable; R2 est un alkyle ou un phényle ou un groupement semblable; et R3 est H, un alkyle ou un alcoxy ou un groupement semblable, ou d'un sel correspondant, ainsi que d'un médicament comprenant un tel composé comme ingrédient actif. Le composé est très efficace pour abaisser la concentration de glucose et de lipides dans le sang.
Honda Haruyoshi
Ishii Fumio
Konno Fujiko
Kotake Jiro
Nagao Yoshihiro
Gowling Lafleur Henderson Llp
Ssp Co. Ltd.
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