C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/28 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/695 (2006.01) C07D 239/38 (2006.01) C07D 239/46 (2006.01) C07D 239/56 (2006.01) C07D 239/60 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 409/12 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07D 487/04 (2006.01) C07D 49
Patent
CA 2216099
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) whew R4 is selected from the group consisitng of -H or-NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, NH2 or R15 and R16 taken together with the -N form 1-pyrrolidino, 1-morpholino or 1- piperidino; and R6 is selected from the group consisting of -H, or halo (preferably -Cl); with the overall proviso that R4 and R6 are not both - H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase.
L'invention concerne des composés à base de pyrimidine-thioalkyle et d'alkyléther de formule (I) ainsi qu'à base de pyrimidine-thioalkyle et d'alkyléther de formule (IA), c'est-à-dire les composés de la formule (I) où R4 est choisi dans le groupe consistant en -H ou NR15R16, où R15 représente -H et R16 H, un alkyle en C1-C6, -NH2 ou bien R15 et R16, pris conjointement avec le -N, forment 1-pyrrolidino, 1-morpholino ou 1-piperidino et où R6 est choisi dans le groupe consistant en -H ou halo (de préférence -CI), à la condition générale que R4 et R6 ne représentent pas tous les deux -H. Les composés de la formule IA, étant des inhibiteurs de la transcriptase inverse virale, s'avèrent efficaces dans le traitement de personnes séropositives au VIH.
Cleek Gary J.
Graber David R.
Morris Joel
Murphy Michael J.
Nugent Richard Allen
Macrae & Co.
Pharmacia & Upjohn Company
LandOfFree
Alpha-substituted pyrimidine-thioalkyl and alkylether... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alpha-substituted pyrimidine-thioalkyl and alkylether..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha-substituted pyrimidine-thioalkyl and alkylether... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2068243