Alpha-substituted tryptophane dipeptoid derivatives

Details Alpha-substituted tryptophane dipeptoid derivatives Alpha-substituted tryptophane dipeptoid derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/20 (2006.01) A61K 31/405 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) A61K 38/04 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/02 (2006.01) C07D 413/02 (2006.01) C07D 471/04 (2006.01) C07F 9/547 (2006.01) C07K 5/04 (2006.01)

Patent

CA 2088996

2088996 9204322 PCTABS00011 Novel .alpha.-substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds of the invention are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the compounds in diagnostic compositions.

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