C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) G01N 33/483 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2657953
Disclosed are antibodies specific for alpha-synuclein conformers and methods related thereto. For example, disclosed are methods of diagnosing a neurodegenerative such as Parkinson's disease, monitoring a neurodegenerative disease progression, and monitoring a neurodegenerative disease treatment using the disclosed antibodies. Assays, kits, and solid supports related to alpha-synuclein and antibodies specific for alpha- synuclein are also disclosed.
La présente invention concerne des anticorps spécifiques de conformères alpha-synucleine et des techniques associées. Par exemple, cette invention concerne des techniques permettant de diagnostiquer une maladie neurodégénérative telle que la maladie de Parkinson, de surveiller une progression de maladie neurodégénérative et de surveiller un traitement de maladie neurodégénérative au moyen des anticorps de l'invention. Cette invention concerne aussi des dosages, des kits et des supports solides associés à alpha-synucleine ainsi que des anticorps spécifiques d' alpha- synucleine..
Federoff Howard J.
Maguire-Zeiss Kathleen
Sullivan Mark
Gowling Lafleur Henderson Llp
University Of Rochester
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