Alpha-tocopherol based vesicles

Details Alpha-tocopherol based vesicles Alpha-tocopherol based vesicles

A - Human Necessities

61

K

167/148, 167/153

A61K 31/355 (2006.01) A61K 9/127 (2006.01)

Patent

CA 1315678

TLC 120A ALPHA TOCOPHEROL-BASED VESICLES ABSTRACT Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.

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