.alpha.v.beta.3 antagonists

Details .alpha.v.beta.3 antagonists .alpha.v.beta.3 antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/46 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2251017

This invention relates to certain novel isoindolone compounds and derivatives thereof, their synthesis, and their use as .alpha.v.beta.3 receptor antagonists. The .alpha.v.beta.3 receptor antagonist compounds of this invention are useful for inhibiting bone resorption, treating and preventing osteoporosis and cancer, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.

Nouveaux composés d'isoindolone et dérivés de ces composés, leur synthèse et leur utilisation comme antagonistes du récepteur .alpha.v.beta.3. Les composés antagonistes du récepteur .alpha.v.beta.3 de cette invention se révèlent utiles pour la prévention de la résorption osseuse, le traitement et la prévention de l'ostéoporose et du cancer et la prévention de la resténose vasculaire, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, les inflammations et le développement des tumeurs.

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