Alpha v integrin receptor antagonists

Details Alpha v integrin receptor antagonists Alpha v integrin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/02 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) A61P 19/10 (2006.01) C07D 211/00 (2006.01) C07D 213/00 (2006.01) C07D 239/02 (2006.01) C07D 241/02 (2006.01) C07D 241/36 (2006.01) C07D 401/02 (2006.01) C07D 405/02 (2006.01) C07D 471/02 (2006.01) C07D 471/04 (2006.01) C07D 487/00 (2006.01)

Patent

CA 2416751

The present invention relates to novel chain-fluorinated alkanoic acid derivatives thereof, their synthesis, and their use as .alpha.v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3 and/or .alpha.v.beta.5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

L'invention concerne de nouveaux dérivés de l'acide alcanoïque à chaîne fluorée, leur synthèse, et leur utilisation en tant qu'antagonistes récepteurs d'intégrine. Plus particulièrement, les composés de l'invention sont des antagonistes des récepteurs d'intégrine .alpha.v.beta.3 et/ou .alpha.v.beta.5 et sont utiles dans l'inhibition de la résorption osseuse, le traitement et la prévention de l'ostéoporose, et l'inhibition de la resténose vasculaire, de la rétinopathie diabétique, de la dégénérescence de la macula, de l'angiogenèse, de l'athérosclérose, d'inflammations, de l'arthrite inflammatoire, d'infections virales, du cancer et de la croissance métastasique.

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