Alpha v integrin receptor antagonists

Details Alpha v integrin receptor antagonists Alpha v integrin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/02 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07D 487/00 (2006.01)

Patent

CA 2421792

The present invention relates to cyclic urea derivatives, their synthesis, and their use as .alpha..nu. integrinreceptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha..nu..beta.3 and /or .alpha..nu..beta.5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, tumor growth and metastasis.

La présente invention concerne des dérivés d'urée cyclique, leur synthèse et leur utilisation comme antagonistes du récepteur de l'intégrine .alpha.v. Plus particulièrement, les composés de l'invention sont des antagonistes des récepteurs de l'intégrine .alpha.v.beta.3 et/ou.alpha.v.beta.5 et peuvent donc être utilisés pour inhiber la résorption osseuse, traiter et prévenir l'ostéoporose, et inhiber la resténose vasculaire, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, l'arthrite inflammatoire, la croissance tumorale et la métastase.

Affiliated with

Also associated with

Rating

Alpha v integrin receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alpha v integrin receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha v integrin receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1766359