Alpha v integrin receptor antagonists

Details Alpha v integrin receptor antagonists Alpha v integrin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/55 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2373937

The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphaV integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaV beta3 and alphaV beta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

La présente invention concerne de nouveaux dérivés de l'acide nonanoique, leur synthèse, et leur utilisation en tant qu'antagonistes du récepteur de l'intégrine .alpha.V. Plus particulièrement, les composés de la présente invention sont antagonistes des récepteurs de l'intégrine .alpha.V beta3 et .alpha.V beta5 et sont utiles pour l'inhibition de la résorption osseuse, pour le traitement de l'ostéoporose, et pour l'inhibition de la resténose vasculaire, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, l'inflammation, l'arthrite inflammatoire, les maladies virales, le cancer, et la croissance tumorale métastatique.

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