C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/02 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/68 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2460269
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
La présente invention concerne des compositions et des procédés utilisés dans la production de populations de particules de réplicons d'alphavirus infectieux défectifs pour la réplication ne contenant pas de particules d'alphavirus compétents pour la réplication, tel que mesuré par le repiquage sur des cellules en culture. Les compositions de l'invention comprennent des molécules d'acides nucléiques de lymphocytes T4 et de réplicons qui permettent de réduire davantage la fréquence prédite de formation de virus compétents pour la réplication et d'optimiser les stratégies et coûts de fabrication.
Caley Ian J.
Dryga Sergey A.
Kamrud Kurt I.
Rayner Jonathan O.
Smith Jonathan F.
Alphavax Inc.
Sim & Mcburney
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