Alphavirus vectors

Details Alphavirus vectors Alphavirus vectors

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01)

Patent

CA 2309835

A modified alphavirus expression vector is provided wherein at least one optimal heterologous splice site is introduced to the alphavirus replicon to prevent aberrant splicing of the alphavirus, which may be Semliki Forest virus following administration of the vector to a host.

L'invention concerne un vecteur d'expression d'alphavirus modifié, selon lequel au moins un site d'épissage hétérologue optimal est introduit dans le réplicon de l'alphavirus pour empêcher tout épissage aberrant de l'alphavirus, qui peut être le virus Semliki Forest, après administration du vecteur à un hôte.

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