Alteration of fc-fusion protein serum half-lives by...

Details Alteration of fc-fusion protein serum half-lives by... Alteration of fc-fusion protein serum half-lives by...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2545539

The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified Fc- fusion protein, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified Fc-fusion protein.

La présente invention concerne une protéine de fusion Fc modifiée, dans laquelle au moins un acide aminé de la région constante de la chaîne lourde sélectionné dans le groupe constitué de résidus d'acide aminé 250, 314 et 428 est substitué par un autre acide aminé qui est différent de celui présent dans la protéine de fusion Fc non modifiée, ce qui modifie l'affinité de liaison pour FcRn et/ou la demi-vie sérique par rapport à la protéine de fusion Fc non modifiée.

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