C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2502904
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 205, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half- life in comparison to the unmodified antibody.
La présente invention porte sur un anticorps modifié de la classe IgG dans lequel au moins un acide aminé de la région constante de la chaîne lourde, sélectionné dans le groupe comprenant les résidus d'acide aminé 250, 314 et 428, est substitué par un autre acide aminé qui est différent de celui présent dans l'anticorps non modifié, ce qui modifie l'affinité de liaison pour FcRn et/ou la demi-vie sérique par rapport à l'anticorps non modifié.
Hinton Paul R.
Tso Yun J.
Tsurushita Naoya
Vasquez Maximiliano
Abbott Biotherapeutics Corp.
Protein Design Labs Inc.
Smart & Biggar
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