C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2522331
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half- life in comparison to the unmodified antibody.
La présente invention concerne un anticorps modifié de la classe IgG, dans lequel au moins un acide aminé de la région constante de chaîne lourde sélectionné dans le groupe constitué des résidus d'acides aminés 250, 314 et 428 est substitué par un autre acide aminé qui est différent de celui qui est présent dans l'anticorps non modifié, modifiant ainsi l'affinité de liaison pour FcRn et/ou la demi-vie de sérum en comparaison avec l'anticorps non modifié.
Hinton Paul R.
Tso J. Yun
Tsurushita Naoya
Vasquez Maximiliano
Abbott Biotherapeutics Corp.
Protein Design Labs Inc.
Smart & Biggar
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