C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/44 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2102848
ABSTRACT OF THE INVENTION ALTERED AFFINITY POLYPEPTIDES OF METAL CHELATE BINDING ANTIBODIES This invention provides a polypeptide having an amino acid sequence including a complementarity determining region (CDR) sequence of a native antibody having an amino acid substitution, the polypeptide having a binding affinity for a metal chelate of EDTA or an EDTA analog that is about equal to or altered from the binding affinity of the native antibody.
Ahrweiler Patricia M.
Moore Margaret D.
Gowling Lafleur Henderson Llp
Hybritech Incorporated
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