Altered affinity polypeptides of metal chelate binding...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/44 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2102848

ABSTRACT OF THE INVENTION ALTERED AFFINITY POLYPEPTIDES OF METAL CHELATE BINDING ANTIBODIES This invention provides a polypeptide having an amino acid sequence including a complementarity determining region (CDR) sequence of a native antibody having an amino acid substitution, the polypeptide having a binding affinity for a metal chelate of EDTA or an EDTA analog that is about equal to or altered from the binding affinity of the native antibody.

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