Altered insulin-like growth factor binding proteins

Details Altered insulin-like growth factor binding proteins Altered insulin-like growth factor binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/30 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/65 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2491917

Altered IGFBPs are able to bind IGF but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by the use of these altered IGFBPs.

Les protéines de liaison modifiées au facteur de croissance analogue de l'insuline (IGFBP) peuvent se lier au facteur de croissance analogue de l'insuline, mais la libération est inhibée par la résistance au clivage de protéases et/ou à la capacité de liaison réduite avec la matrice extracellulaire (ECM). Des modifications ont été apportées à IGFBP-2 au niveau du domaine lieur et de deux motifs d'acides aminés dont on a constaté qu'ils jouaient un rôle important dans la liaison avec ECM. L'utilisation de ces IGFBP modifiés a permis d'inhiber la prolifération à médiation IGF-1 de cellules cancéreuses.

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