Altered peptide ligands

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2438505

The present invention provides compositions comprising altered peptide ligands that elicit immune responses in a subject to a native peptide. This invention also provides methods to raise T cell populations as well as a substantially purified population of said T cells. Altered peptide ligands find applilcation in a wide variety of immunomodulatory protocols, including methods to induce or increase an immune response, as well as in methods to suppress or reduce an undesirable immune response, to a corresponding natural epitope.

L'invention concerne des compositions contenant des ligands peptidiques modifiés qui déclenchent chez un sujet des réactions immunitaires à un peptide natif. Elle concerne aussi des procédés visant à augmenter les populations cellulaires de lymphocytes T ainsi qu'une population sensiblement purifiée de ces lymphocytes T. Les ligands peptidiques modifiés peuvent être utilisés dans une large gamme de protocoles d'immunomodulation, y compris des procédés visant à induire ou à accroître une réaction immunitaire, et des procédés visant à réduire ou à supprimer une réaction immunitaire indésirable à l'égard d'un épitope naturel correspondant.

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