Altered polypeptides with increased half-life

Details Altered polypeptides with increased half-life Altered polypeptides with increased half-life

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/48 (2006.01) C07K 14/61 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2217871

Polypeptides that are cleared from the kidney and do not contain in their original form an Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.

La présente invention concerne la modification de polypeptides qui sont éliminés par le rein et qui ne possèdent pas une région Fc d'IgG dans leur forme originale, laquelle modification consiste en l'introduction d'un épitope d'une région Fc d'IgG permettant une liaison à un récepteur dit de sauvetage, ce qui accroît la demi-vie desdits polypeptides dans la circulation.

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