C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/08 (2006.01) A61K 35/76 (2006.01) A61K 39/275 (2006.01) A61K 39/285 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 31/20 (2006.01) C12N 7/00 (2006.01) C12N 15/863 (2006.01)
Patent
CA 2397675
The invention provides new strains of the Modified Vaccinia Virus Ankara (MVA) that have a strongly reduced virulence for most mammals, especially humans, but nevertheless grows in cells of a continuous cell line approved for the production of a therapeutic agent such as a vaccine. The invention also provides a method for producing said adapted MVA strains. The adapted MVA can be used e.g. for parenteral immunization, as a vector system, or in the active or inactivated from as an adjuvant or as a regulator of the unspecific components of the immune system.
L'invention concerne de nouvelles souches du virus modifié de vaccine Ankara (MVA) dont la virulence a été fortement réduite chez la plupart des mammifères et notamment les humains mais qui se développe néanmoins dans les cellules d'une lignée cellulaire discontinue, adaptée à la fabrication d'un agent thérapeutique tel qu'un vaccin. L'invention concerne aussi un procédé pour produire ces souches MVA adaptées. Les MVA adaptées peuvent être utilisées pour l'immunisation parentale, comme système de vecteurs ou, sous la forme active ou inactivée, comme adjuvant ou comme régulateur des composants non spécifiques du système immunitaire.
Bavarian Nordic A/s
Goudreau Gage Dubuc
Mayr Anton
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