Altering memory by affecting staufen function

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2490535

The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen- dependent protein expression. The present invention further provides methods for a treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal- dependent cognitive task associated with a defect in STAUFEN.

La présente invention concerne des méthodes de criblage d'un agent pharmaceutique à la recherche de sa capacité à moduler la formation d'une mémoire à long terme, la capacité d'une tâche cognitive dépendante de l'hippocampe ou d'une fonction de Staufen. Cette invention a également trait à des méthodes de modulation de la formation d'une mémoire à long terme ou de la capacité d'une tâche cognitive dépendante de l'hippocampe par modulation de l'expression protéique dépendante de Staufen. Ladite invention a, en outre, pour objet des méthodes de traitement d'un défaut dans la formation d'une mémoire à long terme liée à un défaut de Staufen et des méthodes de traitement d'un défaut dans la capacité d'une tâche cognitive dépendante de l'hippocampe liée à un défaut de Staufen.

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