Alternate crystal form of tazofelone

Details Alternate crystal form of tazofelone Alternate crystal form of tazofelone

C - Chemistry, Metallurgy

07

D

C07D 277/14 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2231132

The instant invention provides novel crystalline Form II of (+/-)-5-{[3,5- bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl}-4-thiazolidinone having an x- ray powder diffraction pattern with d spacings at 5.64.ANG., 5.16.ANG., 4.90.ANG., 4.66.ANG. and 4.49.ANG. is useful for treating inflammation, inflammatory bowel disease, allergies, arthritis and hypoglycemia utilizing the novel physical form as well as pharmaceutical compositions containing the same. A process for preparing Form II Tazofelone is described.

Nouvelle forme II cristalline de (+/-)-5-{[3,5-bis(1,1-dimethyléthyl)-4-hydroxyphényl]méthyl}-4-thiazolidinone présentant un schéma de diffraction de la poudre aux rayons X avec des écartements d à 5,64.ANG.; 5,16.ANG.; 4,90.ANG.; 4,66.ANG. et 4,49.ANG.. Cette nouvelle forme cristalline II de tazofelone ainsi que les compositions pharmaceutiques contenant cette dernière, sont utiles pour traiter l'inflammation, les affections intestinales inflammatoires, les allergies, l'arthrite et l'hypoglycémie. On décrit également un procédé de préparation de la forme II de tazofélone.

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