Alternative dimerisation reagents for synthesis of iodixanol

Details Alternative dimerisation reagents for synthesis of iodixanol Alternative dimerisation reagents for synthesis of iodixanol

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) C07C 237/46 (2006.01)

Patent

CA 2695551

This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N'-bis (2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") to iodixanol.

L'invention concerne de manière générale des milieux de contraste non ioniques aux rayons X. Elle a en outre trait à la synthèse d'iodixanol. De manière particulière, elle concerne des réactifs substituts de dimérisation pour la conversion de 5-acétamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophtalamide (« composé A ») en iodixanol.

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