C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) C07K 14/075 (2006.01) C12N 7/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2342396
The present invention provides a recombinant protein having an amino terminus of an adenoviral fiber protein and having a trimerization domain. A fiber incorporating such a protein exhibits reduced affinity for a native substrate than does a wild-type adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the recombinant protein of the present invention.
L'invention concerne une protéine recombinante présentant une terminaison amino d'une protéine fibreuse d'adénovirus et un domaine de trimérisation. Une fibre contenant une telle protéine présente une affinité réduite pour un substrat natif par rapport à un trimère fibreux d'adénovirus. L'invention concerne en outre un adénovirus contenant la protéine recombinante de l'invention.
Bruder Joseph T.
Kovesdi Imre
Roelvink Petrus W.
Wickham Thomas J.
Genvec Inc.
R. William Wray & Associates
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