Alzheimer's disease secretase, app substrates therefor, and...

Details Alzheimer's disease secretase, app substrates therefor, and... Alzheimer's disease secretase, app substrates therefor, and...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2397786

The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and isolates and assays. An enzyme that cleaves the .alpha.-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

L'invention concerne l'enzyme et les opérations enzymatiques destinées au clivage du site de clivage de la .beta.-sécrétase de la protéine APP ainsi que les acides nucléiques, peptides, vecteurs, cellules, isolats de cellules et dosages associés. L'invention concerne aussi une enzyme clivant le site de .alpha.-sécrétase de l'APP. L'invention concerne en outre une protéine APP modifiée ainsi que les acides nucléiques, peptides, vecteurs, cellules, isolats de cellules et dosages associés qui sont particulièrement utiles dans l'identification des préparations thérapeutiques candidates pour le traitement ou la prévention de la maladie d'Alzheimer.

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