Amblyommin, a new active substance for anticoagulant therapy

Details Amblyommin, a new active substance for anticoagulant therapy Amblyommin, a new active substance for anticoagulant therapy

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 14/81 (2006.01) A61K 35/56 (2006.01) A61K 38/57 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339189

-1- Amblyommin, a new active substance for anticoagulant therapy The invention relates to a new active substance amblyommin - for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences - Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn- X-Phe-Glu-, - Lys-Ile-Leu-Phe-X-Gln-Gly- and - Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu- X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

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