Ameliorating agent for insulin resistance

Details Ameliorating agent for insulin resistance Ameliorating agent for insulin resistance

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2678757

Disclosed are an ameliorating agent for insulin resistance and a prophylactic/therapeutic agent for a disease associated with impaired glucose metabolism, each of which comprises a substance which inhibits the expression or activity of CPSF5 protein and/or a substance which inhibits the expression or activity of CPSF6 protein. As the substance, the following substances (a) to (c) and the like are provided: (a) an antisense nucleic acid for a nucleic acid encoding CPSF5 (or CPSF6); (b) siRNA for RNA encoding CPSF5 (or CPSF6); and (c) a nucleic acid which can produce siRNA for RNA encoding CPSF5 (or CPSF6). Further disclosed is a method for the screening of a substance capable of ameliorating insulin resistance, which utilizes a cell capable of producing CPSF5 and/or CPSF6.

L'invention concerne un agent améliorant pour la résistance à l'insuline et un agent prophylactique/thérapeutique pour une maladie associée au métabolisme du glucose défectueux, chacun comprenant une substance qui inhibe l'expression ou l'activité de la protéine CPSF5 et/ou une substance qui inhibe l'expression ou l'activité de la protéine CPSF6. En tant que substance, les substances suivantes (a) à (c) et similaires sont proposées : (a) un acide nucléique anti-sens pour un acide nucléique codant pour CPSF5 (ou CPSF6); (b) ARNsi pour un ARN codant pour CPSF5 (ou CPSF6); et (c) un acide nucléique qui peut produire un ARNsi pour de l'ARN codant pour CPSF5 (ou CPSF6). L'invention concerne en outre un procédé pour le criblage d'une substance capable d'améliorer la résistance à l'insuline, qui utilise une cellule capable de produire CPSF5 et/ou CPSF6.

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