Ameliorating agent for neurogenic pain

Details Ameliorating agent for neurogenic pain Ameliorating agent for neurogenic pain

A - Human Necessities

61

K

A61K 38/43 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2721341

An object of the present invention is to provide a substance which can be used as an active ingredient for improving neuropathic pain having a novel mechanism of action different from those of currently available agents and, therefore, provide an improving agent for neuropathic pain which rarely interacts with currently available agents and also does not have adverse reactions similar to those of currently available agents. An improving agent for neuropathic pain due to a hyperalgesic response of the present invention as a means for resolution is characterized by comprising, as an active ingredient, a lyase (an elimination enzyme) which has an activity of degrading a chondroitin sulfate chain of a chondroitin sulfate proteoglycan, and is typified by chondroitinase ABC which selectively removes chondroitin sulfate and dermatan sulfate of a proteoglycan.

L'objectif de l'invention vise à proposer une substance qui peut être utilisée en tant que principe actif pour améliorer une douleur neurogénique par un nouveau mécanisme d'action qui est différent de ceux des principes classiques et, par conséquent, vise à proposer un agent améliorant la douleur neurogénique qui n'a pas d'effets secondaires défavorables similaires à ceux des agents classiques. L'invention porte sur un agent améliorant pour une douleur neurogénique provoquée par une réponse hyperalgésique. L'agent améliorant est caractérisé en ce qu'il comprend, en tant que principe actif, une lyase capable de décomposer une chaîne chondroïtine sulfate dans un protéoglycane de chondroïtine sulfate, typiquement une chondroïtinase ABC qui peut sélectivement éliminer le chondroïtine sulfate et le dermatane sulfate du protéoglycane.

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